Compounds > 4-[[[[oxo-(4-phenylphenyl)methyl]amino]-sulfanylidenemethyl]amino]benzoic acid
Page last updated: 2024-09-28

4-[[[[oxo-(4-phenylphenyl)methyl]amino]-sulfanylidenemethyl]amino]benzoic acid

Cross-References

ID SourceID
PubMed CID1017047
CHEMBL ID1412068
CHEBI ID112979

Synonyms (19)

Synonym
4-[(4-phenylbenzoyl)carbamothioylamino]benzoic acid
AN-465/41523077 ,
4-({[([1,1'-biphenyl]-4-ylcarbonyl)amino]carbothioyl}amino)benzoic acid
MLS000676426 ,
smr000298980
4-({[(4-biphenylylcarbonyl)amino]carbonothioyl}amino)benzoic acid
STK006898
4-{[(biphenyl-4-ylcarbonyl)carbamothioyl]amino}benzoic acid
CHEBI:112979
AKOS000103315
HMS2663B22
4-[(4-phenylphenyl)carbonylcarbamothioylamino]benzoic acid
bdbm65283
cid_1017047
4-[[[[oxo-(4-phenylphenyl)methyl]amino]-sulfanylidenemethyl]amino]benzoic acid
4-[(4-phenylbenzoyl)thiocarbamoylamino]benzoic acid
CHEMBL1412068
Q27193443
4-({[(biphenyl-4-ylcarbonyl)amino]carbonothioyl}amino)benzoic acid

Drug Classes (1)

ClassDescription
thioureasCompounds of general formula RR'NC(=S)NR''R'''.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (32)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency79.43280.004023.8416100.0000AID485290
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency44.66840.631035.7641100.0000AID504339
LuciferasePhotinus pyralis (common eastern firefly)Potency6.01200.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency5.62340.01846.806014.1254AID624417
thioredoxin reductaseRattus norvegicus (Norway rat)Potency15.84890.100020.879379.4328AID588453
phosphopantetheinyl transferaseBacillus subtilisPotency100.00000.141337.9142100.0000AID1490
ATAD5 protein, partialHomo sapiens (human)Potency5.17140.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency18.35640.000811.382244.6684AID686978
thioredoxin glutathione reductaseSchistosoma mansoniPotency12.58930.100022.9075100.0000AID485364
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency8.91250.011212.4002100.0000AID1030
regulator of G-protein signaling 4Homo sapiens (human)Potency50.11870.531815.435837.6858AID504845
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency70.79460.707936.904389.1251AID504333
IDH1Homo sapiens (human)Potency20.59620.005210.865235.4813AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency17.78280.035520.977089.1251AID504332
chromobox protein homolog 1Homo sapiens (human)Potency50.11870.006026.168889.1251AID540317
pyruvate kinase PKM isoform aHomo sapiens (human)Potency35.48130.04017.459031.6228AID1631; AID1634
ras-related protein Rab-9AHomo sapiens (human)Potency4.46680.00022.621531.4954AID485297
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency29.93490.168316.404067.0158AID720504
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency8.91250.010323.856763.0957AID2662
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.00000.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency16.36010.004611.374133.4983AID624296
survival motor neuron protein isoform dHomo sapiens (human)Potency6.30960.125912.234435.4813AID1458
neuropeptide S receptor isoform AHomo sapiens (human)Potency7.94330.015812.3113615.5000AID1461
Guanine nucleotide-binding protein GHomo sapiens (human)Potency13.94801.995325.532750.1187AID624287; AID624288
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
corticotropin-releasing hormone receptor 2Homo sapiens (human)IC50 (µMol)5.98500.36807.095518.0000AID602180; AID651639
corticotropin releasing factor-binding proteinHomo sapiens (human)IC50 (µMol)5.98500.36807.095518.0000AID602180; AID651639
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
alternatively spliced Trp4Mus musculus (house mouse)EC50 (µMol)4.73070.00033.337010.5907AID434942
corticotropin-releasing hormone receptor 2Homo sapiens (human)EC50 (µMol)53.00001.120011.561736.8000AID602473
corticotropin releasing factor-binding proteinHomo sapiens (human)EC50 (µMol)53.00001.120011.561736.8000AID602473
cardiac alpha tropomyosinSus scrofa (pig)EC50 (µMol)71.48501.83002.37402.9180AID504698
heat shock protein 90Candida albicansEC50 (µMol)3.34800.12006.485533.8530AID2423
troponin I, cardiac muscleHomo sapiens (human)EC50 (µMol)71.48501.83002.37402.9180AID504698
troponin T, cardiac muscle isoform 3Homo sapiens (human)EC50 (µMol)71.48501.83002.37402.9180AID504698
troponin C, slow skeletal and cardiac musclesHomo sapiens (human)EC50 (µMol)71.48501.83002.37402.9180AID504698
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
tetramethylthiourea[no description available]low00thioureas
phenylthiourea[no description available]low00thioureasEC 1.14.18.1 (tyrosinase) inhibitor
N-(4-fluorophenyl)-4-methyl-1-piperidinecarbothioamide[no description available]low00thioureas
1-(1,3-benzodioxol-5-ylmethyl)-3-(4-methylphenyl)thiourea[no description available]low00thioureas
diphenylthiourea[no description available]low00thioureasallergen
1-(2-methoxyphenyl)-3-(2-pyridinyl)thiourea[no description available]low00thioureas
N-[(3-nitroanilino)-sulfanylidenemethyl]benzamide[no description available]low00thioureas
3-cyclohexyl-1,1-bis(2-methylpropyl)thiourea[no description available]low00thioureas
1-(2,5-dimethoxyphenyl)-3-phenylthiourea[no description available]low00thioureas
1-(3-fluorophenyl)-3-(2-pyridinylmethyl)thiourea[no description available]low00thioureas
1-(2-methoxyphenyl)-5-(phenylmethyl)-1,3,5-triazinane-2-thione[no description available]low00thioureas
3-(4-bromophenyl)-6-phenyl-1,4-dihydro-1,3,5-triazine-2-thione[no description available]low00thioureas
3-(4-methylphenyl)-6-phenyl-1,4-dihydro-1,3,5-triazine-2-thione[no description available]low00thioureas
1-(1,3-benzodioxol-5-ylmethyl)-3-(2-methylphenyl)thiourea[no description available]low00thioureas
N-(3-methoxyphenyl)-4-(phenylmethyl)-1-piperazinecarbothioamide[no description available]low00thioureas
1-(1,3-benzodioxol-5-ylmethyl)-3-(3-chloro-2-methylphenyl)thiourea[no description available]low00thioureas
1-(1,3-benzodioxol-5-ylmethyl)-3-(2,5-dimethylphenyl)thiourea[no description available]low00thioureas
3-(4-chlorophenyl)-6-phenyl-1,4-dihydro-1,3,5-triazine-2-thione[no description available]low00thioureas
1-(4-bromophenyl)-3-(2-phenylethyl)thiourea[no description available]low00thioureas
N-[(4-fluoroanilino)-sulfanylidenemethyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide[no description available]low00thioureas
1-(3-chlorophenyl)-3-(phenylmethyl)thiourea[no description available]low00thioureas
1-(4-chlorophenyl)-3-(2-furanylmethyl)thiourea[no description available]low00thioureas
1-(3,4-dichlorophenyl)-3-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-(4-chlorophenyl)-3-(2-phenylethyl)thiourea[no description available]low00thioureas
N-[(3-acetylanilino)-sulfanylidenemethyl]-3-chlorobenzamide[no description available]low00thioureas
N-(2,4-dichlorophenyl)-1-piperidinecarbothioamide[no description available]low00thioureas
2-(4-chlorophenyl)-N-[(2-hydroxy-5-methylanilino)-sulfanylidenemethyl]acetamide[no description available]low00thioureas
1-[(2,4-dichlorophenyl)methyl]-3-phenylthiourea[no description available]low00thioureas
N-[[2-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]-2-thiophenecarboxamide[no description available]low00thioureas
N-(2,4-dimethylphenyl)-4-(phenylmethyl)-1-piperazinecarbothioamide[no description available]low00thioureas
N-[anilino(sulfanylidene)methyl]-5-bromo-2-furancarboxamide[no description available]low00thioureas
1-(phenylmethyl)-3-[4-(trifluoromethoxy)phenyl]thiourea[no description available]low00thioureas
1-(4-methyl-3-nitrophenyl)-3-[(4-methylphenyl)methyl]thiourea[no description available]low00thioureas
1-(2-chlorophenyl)-3-[(2-chlorophenyl)methyl]thiourea[no description available]low00thioureas
1-(3-chloro-4-methoxyphenyl)-3-[2-(4-methyl-1-piperidinyl)ethyl]thiourea[no description available]low00thioureas
2,2-dimethyl-N-[[2-(4-methyl-1-piperidinyl)anilino]-sulfanylidenemethyl]propanamide[no description available]low00thioureas
1-(4-bromophenyl)-3-(2-fluorophenyl)thiourea[no description available]low00thioureas
1-(3,4-dichlorophenyl)-3-(3,5-dimethylphenyl)thiourea[no description available]low00thioureas
tenovin-1[no description available]low00thioureas
N-[[3-(hydroxymethyl)anilino]-sulfanylidenemethyl]-4-phenylbenzamide[no description available]low00thioureas
5-bromo-N-[[4-[(3,5-dimethylphenyl)sulfamoyl]anilino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
N-[(3-acetylanilino)-sulfanylidenemethyl]-5-bromo-3-pyridinecarboxamide[no description available]low00thioureas
3,4-dimethoxy-N-[[4-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
N-[[3-chloro-4-(4-morpholinyl)anilino]-sulfanylidenemethyl]-2-thiophenecarboxamide[no description available]low00thioureas
N-[[3-chloro-4-(4-morpholinyl)anilino]-sulfanylidenemethyl]-2-(4-methoxyphenoxy)acetamide[no description available]low00thioureas
N-[[3-chloro-4-(1-piperidinyl)anilino]-sulfanylidenemethyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide[no description available]low00thioureas
N-[(4-ethylanilino)-sulfanylidenemethyl]-3-methylbutanamide[no description available]low00thioureas
N-[(2-fluoroanilino)-sulfanylidenemethyl]-2-(4-methoxyphenoxy)acetamide[no description available]low00thioureas
N-[[3-chloro-2-(4-morpholinyl)anilino]-sulfanylidenemethyl]-4-methoxy-3-nitrobenzamide[no description available]low00thioureas
N-[[3-chloro-2-(1-piperidinyl)anilino]-sulfanylidenemethyl]-2-thiophenecarboxamide[no description available]low00thioureas
1-[[4-(dimethylamino)phenyl]methyl]-1-(2-furanylmethyl)-3-(4-methoxyphenyl)thiourea[no description available]low00thioureas
N-[[2-methyl-5-(2-oxazolo[4,5-b]pyridinyl)anilino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
2,4-dimethyl-N-[[4-(4-morpholinyl)anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
2-(4-chlorophenyl)-N-[[2-(4-morpholinyl)anilino]-sulfanylidenemethyl]acetamide[no description available]low00thioureas
N-[[2-(4-morpholinyl)anilino]-sulfanylidenemethyl]-4-nitrobenzamide[no description available]low00thioureas
N-[(3,5-dimethoxyanilino)-sulfanylidenemethyl]-3-phenylpropanamide[no description available]low00thioureas
3-methoxy-N-[[2-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
2-methoxy-N-[[2-(1-piperidinyl)anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
1-(4-bromophenyl)-3-(3-methylbutyl)thiourea[no description available]low00thioureas
5-bromo-N-[(2-carbamoylanilino)-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
2-chloro-5-[[[[(3,5-dimethoxyphenyl)-oxomethyl]amino]-sulfanylidenemethyl]amino]benzoic acid[no description available]low00thioureas
3-[[[[[5-(4-chlorophenyl)-2-furanyl]-oxomethyl]amino]-sulfanylidenemethyl]amino]-4-methoxybenzoic acid[no description available]low00thioureas
2-(4-bromophenoxy)-N-[(2-hydroxy-5-methylanilino)-sulfanylidenemethyl]acetamide[no description available]low00thioureas
N-[[5-(5,7-dimethyl-1,3-benzoxazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-2-thiophenecarboxamide[no description available]low00thioureas
N-[[3-(2-oxazolo[4,5-b]pyridinyl)anilino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
5-(3-nitrophenyl)-N-[[2-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
1-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(2,5-dimethylphenyl)-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(2-methoxyphenyl)-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
allylthiourea[no description available]low00thioureasmetabolite
N-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
3-propoxy-N-[sulfanylidene-[3-(trifluoromethyl)anilino]methyl]benzamide[no description available]low00thioureas
N-[[3-chloro-4-(1-piperidinyl)anilino]-sulfanylidenemethyl]hexanamide[no description available]low00thioureas
4-phenyl-N-[sulfanylidene-(2,4,6-trimethylanilino)methyl]benzamide[no description available]low00thioureas
1-[2-(2-methylphenoxy)ethyl]-3-phenylthiourea[no description available]low00thioureas
1-[2-[(3-chloro-4-methoxyphenyl)methylthio]ethyl]-3-phenylthiourea[no description available]low00thioureas
3,4,5-trimethoxy-N-[[2-(4-morpholinyl)anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
1-(3,5-dimethoxyphenyl)-3-(3-pyridinyl)thiourea[no description available]low00thioureas
1-[2-[(4-chlorophenyl)thio]ethyl]-3-(2-methoxyphenyl)thiourea[no description available]low00thioureas
1-(2-methoxyphenyl)-3-[2-[(4-methylphenyl)thio]ethyl]thiourea[no description available]low00thioureas
1-(3-chlorophenyl)-3-(thiophen-2-ylmethyl)thiourea[no description available]low00thioureas
1-(4-ethylphenyl)-3-(phenylmethyl)thiourea[no description available]low00thioureas
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(3-fluorophenyl)-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(4-fluorophenyl)-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(4-fluorophenyl)-1-(pyridin-4-ylmethyl)thiourea[no description available]low00thioureas
1-[2-[(4-chlorophenyl)thio]ethyl]-3-(2,4-dimethylphenyl)thiourea[no description available]low00thioureas
1-(3,5-dimethylphenyl)-3-(3-ethoxypropyl)thiourea[no description available]low00thioureas
1-(2,4-dimethylphenyl)-3-[2-[(4-methylphenyl)thio]ethyl]thiourea[no description available]low00thioureas
1-[2-[(2-methylphenyl)methylthio]ethyl]-3-phenylthiourea[no description available]low00thioureas
4-[[(5-chloro-2-methoxyanilino)-sulfanylidenemethyl]amino]-1-ethyl-3-pyrazolecarboxamide[no description available]low00thioureas
1-(5-chloro-2-methoxyphenyl)-3-[3-(2-oxo-1-pyrrolidinyl)propyl]thiourea[no description available]low00thioureas
1-(4-bromo-2-chlorophenyl)-3-(3-methyl-2-pyridinyl)thiourea[no description available]low00thioureas
3-[[(2,4-dichloroanilino)-sulfanylidenemethyl]amino]-4-methylbenzoic acid[no description available]low00thioureas
N-[[4-(dimethylsulfamoyl)anilino]-sulfanylidenemethyl]-2-phenylacetamide[no description available]low00thioureas
N-[(3-bromoanilino)-sulfanylidenemethyl]-3-phenylpropanamide[no description available]low00thioureas
N-[[3-chloro-2-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]butanamide[no description available]low00thioureas
3,4-dimethyl-N-[sulfanylidene-[2-(trifluoromethyl)anilino]methyl]benzamide[no description available]low00thioureas
1-[4-(difluoromethylthio)phenyl]-3-(phenylmethyl)thiourea[no description available]low00thioureas
1-(2-tert-butylphenyl)-3-cyclohexylthiourea[no description available]low00thioureas
1-(2,6-dimethylphenyl)-3-[3-(2-oxo-1-pyrrolidinyl)propyl]thiourea[no description available]low00thioureas
1-(2,6-diethylphenyl)-3-(1H-indazol-6-yl)thiourea[no description available]low00thioureas
1-[[4-[[[(4-chloro-3-fluoroanilino)-sulfanylidenemethyl]amino]methyl]phenyl]methyl]-3-(4-chloro-3-fluorophenyl)thiourea[no description available]low00thioureas
1-(2,6-diethylphenyl)-3-[2-(3,4-dihydroxyphenyl)ethyl]thiourea[no description available]low00thioureas
1-(2-chlorophenyl)-3-(3-phenylpropyl)thiourea[no description available]low00thioureas
4-benzoyl-N-(4-methoxyphenyl)-1-piperazinecarbothioamide[no description available]low00thioureas
1-(2-chlorophenyl)-3-(2-oxo-1,3-dihydrobenzimidazol-5-yl)thiourea[no description available]low00thioureas
acetylthiourea[no description available]low00acetamides;
thioureas
1,3-dibutyl-2-thiourea[no description available]low00thioureasallergen
n-methylthiourea[no description available]low00thioureasdrug metabolite;
hepatotoxic agent;
human xenobiotic metabolite
thiosemicarbazide[no description available]low00hydrazines;
thiocarboxamide;
thioureas
thiourea[no description available]low00one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
1-(4-tert-butylphenyl)-3-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-(4-methoxyphenyl)-3-(6-methyl-2-pyridinyl)thiourea[no description available]low00thioureas
1-(3-methylphenyl)-3-(2-pyridinyl)thiourea[no description available]low00thioureas
capsazepine[no description available]low00benzazepine;
catechols;
monochlorobenzenes;
thioureas		capsaicin receptor antagonist
(2-bromophenyl)thiourea[no description available]low00thioureas
N-[2-(trifluoromethyl)phenyl]pyrrolidine-1-carbothioamide[no description available]low00thioureas
1-(4-hydroxyphenyl)-3-(3-methoxyphenyl)thiourea[no description available]low00thioureas
5-[[(4-methoxyanilino)-sulfanylidenemethyl]amino]-1H-pyrazole-4-carboxylic acid ethyl ester[no description available]low00thioureas
2-[[sulfanylidene-[[2,2,2-trichloro-1-[[(2-nitrophenyl)-oxomethyl]amino]ethyl]amino]methyl]amino]benzoic acid[no description available]low00thioureas
3-[[sulfanylidene-[[2,2,2-trichloro-1-[[(3-nitrophenyl)-oxomethyl]amino]ethyl]amino]methyl]amino]benzoic acid[no description available]low00thioureas
2-[[sulfanylidene-[[2,2,2-trichloro-1-[(1-oxo-2-phenoxyethyl)amino]ethyl]amino]methyl]amino]benzoic acid[no description available]low00thioureas
N-[(2-chloroanilino)-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
1-[1-(2,3-dihydro-1,4-benzodioxin-3-yl)ethyl]-3-phenylthiourea[no description available]low00thioureas
N-[2,2,2-trichloro-1-[[sulfanylidene-(2,4,6-trimethylanilino)methyl]amino]ethyl]benzamide[no description available]low00thioureas
N-[1-[[anilino(sulfanylidene)methyl]amino]-2,2,2-trichloroethyl]-2-(4-ethylphenoxy)acetamide[no description available]low00thioureas
2-chloro-N-[(2-hydroxy-5-methylanilino)-sulfanylidenemethyl]benzamide[no description available]low00thioureas
1-[2-(4-chlorophenyl)ethyl]-3-(4-fluorophenyl)thiourea[no description available]low00thioureas
N-(4-anilinophenyl)-3-(hydroxymethyl)-1-piperidinecarbothioamide[no description available]low00thioureas
N-(4-chloro-2,5-dimethoxyphenyl)-3-methyl-1-piperidinecarbothioamide[no description available]low00thioureas
3-nitro-N-[[4-[4-(1-oxopropyl)-1-piperazinyl]anilino]-sulfanylidenemethyl]benzamide[no description available]low00thioureas
N-[(4-sulfamoylanilino)-sulfanylidenemethyl]-1,3-benzodioxole-5-carboxamide[no description available]low00thioureas
monastrol[no description available]low00enoate ester;
ethyl ester;
phenols;
racemate;
thioureas		antileishmanial agent;
antimitotic;
antineoplastic agent;
EC 3.5.1.5 (urease) inhibitor
2,2-dimethyl-N-[[4-(pyridin-4-ylmethyl)anilino]-sulfanylidenemethyl]propanamide[no description available]low00thioureas
sulfathiourea[no description available]low00substituted aniline;
sulfonamide antibiotic;
thioureas		antibacterial drug;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor
thiocarlide[no description available]low00thioureas
n-ethylthiourea[no description available]low00thioureas
thiophanate[no description available]low00benzimidazole precursor fungicide;
carbamate ester;
carbamate fungicide;
thioureas		antifungal agrochemical
thiophanate[no description available]low00benzimidazole precursor fungicide;
carbamate ester;
carbamate fungicide;
thioureas		antifungal drug
N-[2,2,2-trichloro-1-[[(2,6-dichloroanilino)-sulfanylidenemethyl]amino]ethyl]carbamic acid (phenylmethyl) ester[no description available]low00thioureas
3,4-dimethoxy-N-[(2-methyl-4-nitroanilino)-sulfanylidenemethyl]benzamide[no description available]low00thioureas
1-(3-chlorophenyl)-3-(9-cyclopentyl-9-azabicyclo[3.3.1]nonan-3-yl)thiourea[no description available]low00thioureas
1-(9-cyclopentyl-9-azabicyclo[3.3.1]nonan-3-yl)-3-(3,5-dimethylphenyl)thiourea[no description available]low00thioureas
N-(2,4-dimethoxyphenyl)-3-(6-methyl-1H-benzimidazol-2-yl)-1-piperidinecarbothioamide[no description available]low00thioureas
N-[[3-[(3-chlorophenyl)sulfamoyl]-4-methylanilino]-sulfanylidenemethyl]-4-fluorobenzamide[no description available]low00thioureas
4-[[(3,4-dimethoxyphenyl)methyl-[(4-methylanilino)-sulfanylidenemethyl]amino]methyl]benzoic acid[no description available]low00thioureas
1-(6-methyl-2-pyridinyl)-3-[3-(trifluoromethyl)phenyl]thiourea[no description available]low00thioureas
N-[4-(difluoromethoxy)phenyl]-4-(phenylmethyl)-1-piperazinecarbothioamide[no description available]low00thioureas
1-(2-furanylmethyl)-3-(2-methylphenyl)-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
1-[2-(dimethylamino)ethyl]-3-(2,4-dimethylphenyl)-1-(thiophen-2-ylmethyl)thiourea[no description available]low00thioureas
5-[[(3,4-dichloroanilino)-sulfanylidenemethyl]amino]-1H-pyrazole-4-carboxylic acid methyl ester[no description available]low00thioureas
3-(3-chloro-2-methylphenyl)-1-[(4-methylphenyl)methyl]-1-(3-pyridinylmethyl)thiourea[no description available]low00thioureas
2-(2,4-dibromophenoxy)-N-[[3-(hydroxymethyl)anilino]-sulfanylidenemethyl]acetamide[no description available]low00thioureas
1-[2-[(4-chlorophenyl)thio]ethyl]-3-(4-methylphenyl)thiourea[no description available]low00thioureas
1-(2-ethyl-6-methylphenyl)-3-[(1-methyl-2-pyrrolyl)methyl]thiourea[no description available]low00thioureas
1-(1-adamantyl)-3-(3,4-dimethoxyphenyl)thiourea[no description available]low00thioureas
N-[(3-hydroxyanilino)-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00thioureas
4-chloro-N-[(4-ethoxy-2-nitroanilino)-sulfanylidenemethyl]-2,5-dimethyl-3-pyrazolecarboxamide[no description available]low00thioureas
3-nitro-N-[(3-sulfamoylanilino)-sulfanylidenemethyl]benzamide[no description available]low00thioureas
1-(3,3-dimethylbutan-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea[no description available]low00thioureas
5-[[(2-methylanilino)-sulfanylidenemethyl]amino]-1H-pyrazole-4-carboxylic acid methyl ester[no description available]low00thioureas
3-(3-chloro-4-methoxyphenyl)-1-(2-methoxyethyl)-1-(1-propan-2-yl-4-piperidinyl)thiourea[no description available]low00thioureas
2-[4-[[[[(2,4-dichlorophenyl)-oxomethyl]amino]-sulfanylidenemethyl]amino]-3-methylphenyl]-3,3,3-trifluoro-2-hydroxypropanoic acid ethyl ester[no description available]low00thioureas
1-(3-chlorophenyl)-3-[2-(dimethylamino)-2-phenylethyl]thiourea[no description available]low00thioureas
1-(4-methoxyphenyl)-3-(1-thiophen-2-ylpropan-2-yl)thiourea[no description available]low00thioureas
1-[4-[[4-[[(2-methoxyanilino)-sulfanylidenemethyl]amino]cyclohexyl]methyl]cyclohexyl]-3-(2-methoxyphenyl)thiourea[no description available]low00thioureas
1-[3-(dimethylamino)propyl]-1-(phenylmethyl)-3-[3-(trifluoromethyl)phenyl]thiourea[no description available]low00thioureas
4-bromo-N-[(4-ethoxy-2-nitroanilino)-sulfanylidenemethyl]-2-methyl-3-pyrazolecarboxamide[no description available]low00thioureas
1-(5-chloro-2,4-dimethoxyphenyl)-3-(phenylmethyl)thiourea[no description available]low00thioureas
1-(2-furanylmethyl)-3-(3-methoxyphenyl)-1-[2-(2-methyl-1H-indol-3-yl)ethyl]thiourea[no description available]low00thioureas
1-[2-[(4-pentoxyphenyl)methylthio]ethyl]-3-phenylthiourea[no description available]low00thioureas
noxythiolin[no description available]low00thioureas
amocarzine[no description available]low00C-nitro compound;
N-methylpiperazine;
secondary amino compound;
thioureas		antinematodal drug
salubrinal[no description available]low00aminal;
organochlorine compound;
quinolines;
secondary carboxamide;
thioureas
ki11502[no description available]low00aromatic ether;
benzamides;
quinolines;
thioureas		antineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
3-(3-chlorophenyl)-1-[(1-methyl-3-indolyl)methyl]-1-[3-(4-morpholinyl)propyl]thiourea[no description available]low00thioureas
1-(3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)thiourea[no description available]low00thioureas
tenovin-6[no description available]low00monocarboxylic acid amide;
tertiary amino compound;
thioureas		antineoplastic agent;
p53 activator;
Sir2 inhibitor
N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide[no description available]low00thioureas
ConditionIndicatedRelationship StrengthStudiesTrials
Inflammation0low10
Innate Inflammatory Response0low10